Glycogen storage disease – Adult PRKAG2
A. Basophilic intracytoplasmic inclusions (indicated by arrows) are seen in a number of myocytes. Other myocytes appear pale with eosinophilic granular material in the cytoplasm. H&E. B. The inclusions are stained with periodic acid Schiff and are resistant to digestion with diastase indicative of abnormal glycogen accumulation.