Cardiac Amyloidosis - XV

This is a transmission electron micrograph of and endomyocardial biopsy showing perimyocytic deposition of amyloid. The amyloid fibrils, measure and average of 10 nanometers in diameter and form an electron dense deposit. The upper right image shows several cardiac myocytes surrounded by amyloid.  The white rectangles show areas of close up which is in turn shown at higher magnification. Extracellular matrix components such as collagen fibrils can easily be distinguished from amyloid fibrils.